Prevent aging by strengthening immune cells
Aging affects all of us, but its unpleasant effects can probably be prevented.In a new study, scientists have found an anti-aging immunotherapy that boosts immune cells to better cleanse the damaged cells involved in the aging process.
One of the main causes of physical signs of aging are old cells. These cells no longer divide and do not die. When we are young, the immune system recognizes and destroys these cells, but naturally this ability diminishes over time, which means that aging cells accumulate in the body over time, causing the effects of aging and disease. Are related to it.
So in this research, researchers at the University of California, San Francisco, looked for a way to boost immune cells. They wanted to reuse T cells, which are responsible for killing old cells.
The researchers found that these cells could be reactivated using fat-soluble antigens, resulting in a reduction in aging cells. According to the researchers, T cells are effective for two reasons: first, there are no receptors that activate them on other cells, so this treatment can only be specific to this issue, and second, they are inactivated after a while, so it is irreversible. Treatment is prevented.
The researchers tested the treatment on mice that had two different side effects that contributed to the increase in aging cells. One group of mice was obese and the other group had pulmonary fibrosis. Both groups showed a decrease in aging cells after treatment compared to the control group.
Subsequent experiments on human cells showed that T cells could also kill our aging cells, but tests on humans must be performed to confirm this.
A spin-off company is working on the issue, and a clinical trial is expected in the next few years.
Early research has been promising, and in some studies the health of mice and even their lifespan has increased.
Modern man in search of the elixir of life – science seeks “curable aging.”Cancer, heart disease, stroke,. All occur in old age and primarily due to the aging process. Every seven or eight years, as the human age increases, the risk of death doubles. It can be said that we live the first five decades of life without any serious health challenges.
“One day at the age of fifty we wake up with pain somewhere in our body or sagging skin, but bad luck manifests itself in time,” Alex Mashakis wrote in the Guardian. Let us know if there is a tumor, or advanced osteoarthritis, or heart problems in our body.
The death of a 50-year-old man is premature death, but somewhere in the mid-60s of our lives, an abyss appears before our eyes that we often have no choice but to cross carefully. The movements we used to do smoothly and easily are now becoming more difficult for us, our eyesight and hearing کم are gradually weakening, and we are facing frustrating and embarrassing problems: Why do I not feel the tip of my big toe? What happened to my back?
The body has worked tirelessly over the years and the effects of those activities have piled up; “Problematic accumulation of old cells”, dangerous mutations in other cells, permanent weakness of the immune system, and general depletion of body structures suddenly predispose us to a range of age-related diseases: cancer, cardiovascular disease, Blood pressure, dementia. The risk of death of a ten-year-old human being is 0.00875 (eight hundred and seventy-five hundred thousandths) and at the age of 65 this risk reaches one percent. When we reach the age of 92, we will reach one in five people.
Is there a cure?
Biologist Andrew Steele believes that aging should be treated as a treatable disease. But if we really had a cure for aging, what would it mean to us?When Andrew Steele shares his thoughts about aging and that one day we may treat aging like any other disease, he is often treated with disbelief or even violence. Aging is an inevitable reality for us. We are born, we grow and we grow old, it has been the same for thousands of years, but what if there is another way?
He has recently focused on reading a book on biogerontology, the scientific study of aging. In this book, Steele discusses a future in which our lives continue and continue. Steele calls aging “the greatest human problem of our time” and aging “the greatest cause of suffering in the world.”
In his book Ageless: The New Knowledge of Aging Without Aging, Steele writes: “The dream of anti-aging medicine comes true by identifying the root causes of organ dysfunction due to aging, slowing down the process or reversing it altogether. . » These root causes are what biomarkers are known to be characteristic symptoms. If scientists can count those symptoms, “we can find treatments that slow down the whole aging process and delay the onset of disease.”
There is no hope that we can live longer with this method, but we can spend more years of our lives in health. They think they are going to live longer, but in a miserable unpleasant situation. They think they will live longer in the eighties or nineties and spend, say, 50 years in nursing homes. This idea is not logically and practically possible. No one wants to suffer for many years of their lives. “It’s strange that some people think scientists are looking for such a thing.”
Over the past three decades, bio-geriatric research has accelerated and achieved exciting success. A 2015 study published by the Mayo Clinic in the United States found that using a combination of a cancer drug and a diet control drug, old cells were killed in some mice, some of the signs of aging Were reversed, including improving heart function.
Other studies have shown that rats, worms, and insects increase the lifespan of mice, although they are also associated with side effects such as immunosuppression and hair loss. Last year, researchers in Texas were able to extend their average lifespan by three months, which is more than a decade by human age, by transplanting young mouse stem cells into older mice.
“The pace of change is staggering,” Steele said of recent developments. Recent research has shown that a combination of hormones and drugs can help rejuvenate the thymus gland (which helps the immune system but declines rapidly with age).
In Ageless, Steele writes that the body of evidence provides a Chinese introduction to and prediction of aging. “The future will not be far off, and many dramatic improvements can be made when people of this era realize it,” he said.
Human life will be longer, but not all at once, but gradually: one year, another year, and once we turn 150 years old. In Ageless, Steele speaks of a generation of humans who grow up and know they are finally dying, but with the help of a series of new therapies, each of which is more effective than the last.
We are not talking about the elixir of magic
What Steele is talking about is not immortality; Death will continue in the normal course of life. If you cross the street staring at your mobile phone, or fall off a ladder, or if you are unlucky enough to be hit by a missile in a war zone, or if you get a disease for which a vaccine has not yet been developed, you are no longer a scientist. It does not occur to you, but in the future, life expectancy will obviously be much longer than what we see today.
Does Steel expect us to see a large number of 150-year-olds one day go back and forth as passionately and energetically as 20-year-olds? Yes, if all this research goes well, why not?
200-year-olds playing in a football park? Definitely… The problem is that it is strange to say that we will have 150 year olds who look like 20 year olds.
With this in mind, the biggest question he is asked is, what about the task of population growth?
Many people find his views strange or inhuman or ungodly rather than helpful to human society. What I’m saying is an idea that can help treat cancer, heart disease, stroke, and so on. Each of these things can make everyone admire you, but as soon as you come up with a potentially effective way to deal with these diseases, you suddenly turn into a crazy scientist who wants to push the planet to the brink of explosion.
We have to think beyond
Steele sees existing thinking as a major obstacle: an “unbelievable prejudice against the status quo,” which sees aging as an inevitable process and condemns man to accept it. If we lived in a society where there was no aging and suddenly within a few decades, two-thirds of people would become weak, lose their physical ability, lose their mental strength, and suddenly die of painful diseases. He believes that one day biologics will finally be able to transform the role of medicine from “the first reaction to a disease” to “the first way to prevent a disease.”
It is death that makes life meaningful
Writing a book about aging is also a good way to rethink your lifestyle. Steel runs more these days than ever before and pays more attention to the amount of food it consumes daily.
We are accustomed to going through three stages of life: learning in our youth, working in middle age, and retiring in old age; But what if we were to live more than 100 years? Do we go to school again at age 60 or do we decide to change jobs, or given that we know we have a century or more to live on? At the age of 40, do we think of a change in our lives?
And what about death? When Steele is asked if he thinks that the time will come when death becomes a kind of choice, he answers: Death is inevitable and that is what gives life meaning or introduces a kind of poetry into human life, but I think most people would be happier if there were fewer deaths on Earth. Of course, not all my studies and efforts are for less death to occur, but in my efforts to be healthier in the last years of life, to fight disease more, and to suffer less; But if all this means less death, I do not think it is a bad thing.